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@naval: Expectations are a one-way ratchet.
@navalbookmarkx
TL;DR. Expectations only climb — once raised, they rarely come back down.
February 12, 2026
2026-02-123 itemsX×3
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@tbpn: “This is going to be a trillion-dollar drug.” @hubermanlab says retatrut…
@tbpnbookmarkx
TL;DR. Huberman calls retatrutide a "trillion-dollar drug" after Phase III trials showed up to 33% body weight loss in six months.
Takeaways
- Retatrutide drove ~1/3 body weight loss in 6 months — a step-change beyond current GLP-1s like Ozempic/Mounjaro.
- Still in Phase III; "some degree of muscle" loss hinted at but cut off in the clip.
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@bwarrn: Last year, I gave up on my YC-backed company. I would’ve done it earli…
@bwarrnbookmarkx
TL;DR. A YC founder explains he should've quit his funded startup sooner — co-founder fit mattered more than the brand, money, or paper-perfect setup.
Takeaways
- YC pedigree and funding don't compensate for a mismatched co-founder relationship.
- "On paper, everything was set up perfectly" — the most dangerous kind of startup, because the external validation delays the hard internal call.
- Sunk-cost thinking around YC status likely kept him in longer than was rational.