digest

March 21, 2026

2026-03-21
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Codie is wrong…

@JesseTinsleyx

TL;DR. Jesse Tinsley pushes back on Codie, arguing founders must own delusional optimism, relentless pace, and radical clarity on what to build.

Takeaways

  • Founder job description in three: delusional optimism, push the team faster, radical clarity on what to build.
  • Framed as a direct rebuttal to "Codie" — disagreement is the hook, not the substance.
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lots of AI cos starting to experiment with paid marketing so here’s my take:

@andrewchenthreadx

TL;DR. Paid marketing is a tax on weak defensibility—if you can't out-spend incumbents, you're just renting growth.

Takeaways

  • Paid acquisition scales with your wallet, not your moat; whoever bids highest wins until you run out of money.
  • Build channels that get cheaper as you grow (virality, content, network effects)—otherwise CAC compounds against you.
  • For AI cos specifically: if your only growth lever is ads, you're competing on capital with OpenAI/Google, a fight you lose.
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@HansAmato thread (2): @HansAmato: You didn't "lose your edge" in your 30s. Y…

@HansAmatothreadx

TL;DR. That "lost edge" in your 30s isn't aging — it's a broken methylation cycle starving your brain of neurotransmitter cofactors, and your doctor never tested for it.

Takeaways

  • Get homocysteine tested; above 8 signals a methylation problem regardless of how you feel.
  • Use active B vitamins (methylfolate, methylcobalamin, P5P) — not the cheap cyanocobalamin in drugstore multivitamins your body can't convert.
  • Creatine handles ~40% of your methylation burden; glycine/collagen and adequate animal protein (methionine) refuel the cycle.
  • Low stomach acid from chronic stress and coffee blocks B12 absorption — fix the gut or oral B12 won't stick.